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. 2023 Mar 15;615(7954):920–924. doi: 10.1038/s41586-023-05812-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — A. PET scan at baseline and after 2 cycles of treatment. B. Computed tomographic scans of target lesions and spleen from a 19-year-old with relapsed KMT2Ar AML, previously treated with three prior lines of therapy including 2 allogeneic stem cell transplants and local radiation to the spleen and abdominal nodes, received revumenib at 276 mg PO q12h (Arm A), achieved CRh, MRD negative remission with resolution of extramedullary disease in abdominal nodes and spleen. AML, acute myeloid leukaemia; AP, anterior-posterior; CRh, complete remission with partial haematologic recovery; D, day; FDG, fluorodeoxyglucose; MRD, minimal or measurable residual disease; PET, positron emission tomography; PO, by mouth; q12h, every 12 h; SUV, standardized uptake value.