Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 15;615(7954):884–891. doi: 10.1038/s41586-023-05828-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 19 — a-d. Pairwise comparisons of F2S performance under different imaging conditions. Pairwise comparisons (two-sample rank-sum tests; two-sided) of indicators in each performance measure in Fig. 5e–h. The heatmap presents the significance, i.e., p-value. The top row (mean) shows the statistics of the average. a. Fluorescence dynamics (fits compared to raw fluorescence); b. Spiking (fits compared to ground-truth spiking dynamics); c. F-score (spike detectability) using a linear F2S model; d. Spike-timing error using a linear F2S model. e-i. Statistics of F2S fits using a nonlinear model. e. Example trace and fit of a cell using a nonlinear F2S model – using the same conventions as Fig. 5d-bottom. Top, variance explained of fluorescence dynamics, 93%; bottom, variance explained of spiking, 13%. f-g. Performance of fitting activity profiles. Violin plots, lines from top to bottom: 75%, 50%, 25% of data, respectively. f. Fluorescence dynamics; g. Spiking. h. Spike detectability. i. Spike-timing error.