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. Author manuscript; available in PMC: 2023 Mar 30.
Published in final edited form as: Nature. 2022 Oct 26;611(7935):387–398. doi: 10.1038/s41586-022-05365-x

Extended Data Fig. 5. AML-specific loops associated with sample-specific open chromatins and gene expression.

Extended Data Fig. 5.

a, Hi-C maps for the MEIS1 and ERG gene regions. Left lower halves are for AML samples and the right upper halves are for HSPC and PBMC. The loops are absent in all three PBMC samples (only one is plotted) and less frequent in the four HSPC samples (only one is plotted). b-c, RNA-Seq, CUT&Tag for H3K27ac and H3K27me3, and ATAC-Seq data for regions surrounding the three genes. Purple arcs indicate chromatin loops predicted in at least two AML samples. Shown in the figure are two representative AML samples.