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. 2023 Mar 30;114:154753. doi: 10.1016/j.phymed.2023.154753

Fig. 7.

Fig 7

Deh inhibited the interaction between Akt and PDPK1 to promote phosphorylation of Akt protein. PDPK1/p-Akt/ Nrf2 protein expression (A) in mice model; PDPK1/p-Akt/ Nrf2 protein expression (B) in vitro model; PDPK1 expression in lung tissue of mice model (Immunohistochemistry, C); p-Akt expression in lung tissue of mice model (Immunohistochemistry, D); PDPK1 and p-Akt expression in vitro model (Immunofluorescence, E); the combination of PDPK1 and Akt in vitro (co-immunoprecipitation, F); the combination of Akt and PDPK1 in vitro (co-immunoprecipitation, G); CA inhibited the interaction between Akt and PDPK1 (H and I). Sham, control mice group; Model, ALI mice group; Low/Med/High, ALI mice with 7.5, 15, 30 mg/kg of CA group. Control, control group; Control, control group; LPS+ATP, vitro model of ALI group; Low/Med/High, vitro model of ALI with 10, 20 or 40 μM of CA group; **p < 0.01 compared with control mice or control group; ## p < 0.01 compared with ALI mice or vitro model of ALI group. Number of experiments = 3.