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. 2023 Mar 29;14(3):224. doi: 10.1038/s41419-023-05709-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A, C CCK-8 assays showed that Alisertib (5 μmol and 10 μmol) treatment significantly suppressed cell proliferation in 8305 C (A) and CAL-62 (C) cells in a dose-dependent pattern. B, D After treatment with the indicated concentration of Alisertib for 2 days, the migration/invasion assay was performed in 8305 C (B) and CAL-62 (D) cells. Representative images are shown. The above data are presented as the mean ± SD of three independent experiments. E Five representative tumors from NSG mice injected with CAL-62 are shown, n = 5 mice per group. The subcutaneous xenografts were dissected and are shown on day 13. F, G Tumor volumes were measured with growth curves (F) and tumor weights (G) in the control group (DMSO) and Alisertib group (30 mg/kg). H Representative IHC images and p-Aurora-A and Ki-67 staining in xenograft tumor specimens of control and Alisertib groups are shown. p-Aurora-A and Ki-67 expression were significantly decreased after treatment with Alisertib. Scale bars, 50 μm. The data are presented as the mean ± SD. All *P < 0.05, **P < 0.01, ***P < 0.001, compared with the control group.