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. 2023 Mar 29;13:5153. doi: 10.1038/s41598-023-32276-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between risk signature and immunotherapy. (A) Correlation between risk scores and immune checkpoints. (B) Distribution of PD-L1 protein levels in high-risk and low-risk populations based on the TCPA dataset. (C) Distribution of TMB in high- and low-risk populations based on TCIA. (D) TIDE scores and response outcomes of immunotherapy in LUAD patients. Distribution of risk scores among TIDE predicted immunotherapy response or non-response groups, chi-square. p < 0.001. (E) Distribution of risk scores among immunotherapy responders and non-responders. (F, G) Association of risk score with OS and PFS in patients receiving immunotherapy (ns: no significant difference. (***p < 0.001; **p < 0.01; *p < 0.05).