Table 2.

Important N-glycosylation events in liver cancer.

Protein	N-glycosylation events in liver cancer	Outcome/Application
E-Cadherin	Reduce bisecting N-glycan structure	The interaction between E-Cadherin and β-catenin is weakened, and β-catenin enters the nucleus to activate the Wnt signaling pathway and promote the EMT process
CD44	Increase sialylation levels	Promote the intercellular adhesion
Integrin	Raise sialylation and core fucosylation levels	Inhibit the proliferation of liver cancer cells
Fibronectin	Elevate sialylation levels	Influence its interaction with integrins, altering cell adhesion
Laminin	Increase the formation of β1, 6-branch	Enhance intercellular adhesion.
AFP	Expand core fucosylation levels	More reliable clinical diagnostic and prognostic indicator of liver cancer
AGP	Raise sialylation levels	Increase diagnostic accuracy of liver cancer
Haptoglobin	Widen sialylation levels, lessen the formation of N-glycan branching structure	Reduce false negative results of diagnosis

N-Acetylneuraminic acid N-Acetylglucosamine Mannose Galactose