Table 2.

Subclassification information and the number of substage samples in the D subtype

Stages	Substages (n = sample number)
Non-tumor stage (NT stage)	1 (n = 150), 1_1 (n = 1), 1_2 (n = 3), 1_3 (n = 7), 1_4 (n = 4), 1_5 (n = 1), 1_6 (n = 1)
Low-grade intraepithelial neoplasia stage (LGIN stage)	2_1 (n = 22), 2_2 (n = 11),
	2_3 (n = 21), 2_4 (n = 8)
High-grade intraepithelial neoplasia stage (HGIN stage)	3_1 (n = 13), 3_2 (n = 9),
	3_3 (n = 24), 3_4 (n = 25)
Minimally invasion adenocarcinoma stage (MIA stage)	4 (n = 5)
Duodenal adenocarcinoma stage (DAC stage)	5 (n = 20)