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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Psychol Med. 2022 Sep 30;53(12):5767–5777. doi: 10.1017/S0033291722002999

Table 2.

Genetic Correlations of PTSD and Alcohol Phenotypes in people of EA ancestry

PTSD Phen. PTSD Phen. Data Source Alcohol Phen. Alcohol Phen. Data Source rG s.e. CI LB CI UB p value FDR Adj. p value
PTSD Re-Exp MVP DPW GSCAN −0.094 0.051 −0.194 0.007 0.067 0.094
PTSD Re-Exp MVP DPW GSCAN and UKB −0.042 0.037 −0.115 0.030 0.253 0.270
PTSD Re-Exp MVP DPW UKB −0.084 0.039 −0.160 −0.007 0.033* 0.055
PTSD PGC DPW GSCAN −0.121 0.078 −0.275 0.033 0.124 0.147
PTSD PGC DPW GSCAN and UKB −0.073 0.054 −0.179 0.033 0.176 0.194
PTSD PGC DPW UKB −0.072 0.054 −0.178 0.034 0.184 0.203
PTSD Re-Exp MVP AUDIT-C MVP −0.241 0.044 −0.326 −0.155 3.68 × 10−8* 3.93 × 10−7*
PTSD Re-Exp MVP AUDIT-C UKB −0.188 0.048 −0.282 −0.094 8.29 × 10−5* 0.0003*
PTSD PGC AUDIT-C MVP −0.417 0.074 −0.562 −0.272 1.62 × 10−8* 2.59 × 10−7*
PTSD PGC AUDIT-C UKB −0.225 0.068 −0.358 −0.092 9.00 × 10−4* 0.003*
PTSD Re-Exp MVP AUDIT-T 23andMe −0.122 0.113 −0.343 0.099 0.278 0.278
PTSD Re-Exp MVP AUDIT-T UKB −0.132 0.047 −0.224 −0.039 0.005* 0.013*
PTSD PGC AUDIT-T 23andMe −0.230 0.144 −0.512 0.051 0.109 0.134
PTSD PGC AUDIT-T UKB −0.111 0.065 −0.238 0.016 0.087 0.111
PTSD Re-Exp MVP Max. Alc. MVP 0.294 0.054 0.187 0.400 7.23 × 10−8* 5.78 × 10−7*
PTSD PGC Max. Alc. MVP 0.294 0.087 0.124 0.464 7.00 × 10−4* 0.002*
PTSD Re-Exp MVP AUDIT-P UKB 0.132 0.059 0.016 0.248 0.026* 0.044*
PTSD PGC AUDIT-P UKB 0.374 0.092 0.195 0.554 4.32 × 10−5* 0.0002*
PTSD Re-Exp MVP AUD MVP 0.311 0.044 0.224 0.399 2.70 × 10−12* 8.64 × 10−11*
PTSD PGC AUD MVP 0.289 0.082 0.129 0.449 4 × 10−4* 0.001*
PTSD Re-Exp MVP AD PGC 0.533 0.130 0.278 0.788 4.19 × 10−5* 0.0002*
PTSD PGC AD PGC 0.472 0.152 0.173 0.770 0.002* 0.005*

Note: PTSD, Posttraumatic Stress Disorder; EA, European ancestry; Phe., phenotype; rG, genetic correlation; s.e., standard error; CIs, confidence intervals; LB, lower bound; UB, upper bound; Re-Exp, reexperiencing; MVP, Million Veteran Program; PGC, Psychiatric Genomics Consortium; AD, Alcohol Dependence; AUD, Alcohol Use Disorder, Max. Alc., Maximum Alcohol Intake, AUDIT, Alcohol Use Disorder Identification Test; T, total; P, problems; C, consumption; DPW, Drinks per Week; UKB, UK Biobank; GSCAN, GWAS & Sequencing Consortium of Alcohol and Nicotine Use. Unadjusted and false discovery rate (FDR) adjusted p values < 0.05 are noted by one asterisk on their corresponding columns