Table 3.
Genetic Correlations of PTSD and Alcohol Phenotypes in people of AA ancestry
| PTSD Phe. | PTSD Phe. Data Source | Alcohol Phe. | Alcohol Phe. Data Source | rG | s.e. | CI LB | CI UB | p value | FDR Adj. p value |
|---|---|---|---|---|---|---|---|---|---|
| PTSD | PGC | AUDIT-C | MVP | 0.145 | 0.209 | −0.265 | 0.554 | 0.489 | 0.719 |
| PTSD Re-Exp | MVP | AUDIT-C | MVP | 0.699 | 0.328 | 0.057 | 1.340 | 0.033* | 0.264 |
| PTSD | PGC | Max. Alc. | MVP | −0.123 | 0.342 | −0.794 | 0.548 | 0.719 | 0.719 |
| PTSD Re-Exp | MVP | Max. Alc. | MVP | −0.275 | 0.504 | −1.260 | 0.713 | 0.586 | 0.719 |
| PTSD | PGC | AUD | MVP | 0.182 | 0.185 | −0.180 | 0.544 | 0.325 | 0.719 |
| PTSD Re-Exp | MVP | AUD | MVP | 0.266 | 0.270 | −0.263 | 0.796 | 0.324 | 0.719 |
| PTSD | PGC | AD | PGC | 0.233 | 0.305 | −0.365 | 0.832 | 0.445 | 0.719 |
| PTSD Re-Exp | MVP | AD | PGC | 0.195 | 0.522 | −0.829 | 1.220 | 0.709 | 0.719 |
Note: PTSD, Posttraumatic Stress Disorder; Phe., phenotype; rG, genetic correlation; s.e., standard error; CIs, confidence intervals; LB, lower bound; UB, upper bound; Re-Exp, reexperiencing; MVP, Million Veteran Program; PGC, Psychiatric Genomics Consortium; AD, Alcohol Dependence; AUD, Alcohol Use Disorder; Max. Alc., Maximum Alcohol Intake; AUDIT, Alcohol Use Disorder Identification Test; C, consumption. The p value < 0.05 is noted by one asterisk. None passed FDR adjustment.