Fig. 2.

ICAM-1, VCAM-1, LFA-1, and VLA-4 are upregulated in stasis dermatitis and remain upregulated in lipodermatosclerosis. Samples were obtained from healthy individuals (A–D), patients with stasis dermatitis (E–H), and patients with lipodermatosclerosis (I–L). Cryosections of all skin samples were immunohistochemically stained with monoclonal antibodies against ICAM-1, VCAM-1, LFA-1, and VLA-4. The bar indicates a length of 150 µm. Reprinted with permission from Ref. [34], with permission from Acta Dermato-Venereologica. ICAM-1 intercellular adhesion molecule 1, VCAM-1 vascular cell adhesion molecule 1, LFA-1 lymphocyte function-associated antigen 1, VLA-4 very late antigen 4