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. 2023 Mar 16;14:1146848. doi: 10.3389/fphar.2023.1146848

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Copyright © 2023 Jeanblanc, Sauton, Houdant, Fernandez Rodriguez, de Sousa, Jeanblanc, Bodeau, Labat, Soichot, Vorspan and Naassila.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dose-response effects on alcohol intake in both males (n = 9) and females (n = 10) for R(+)-Baclofen (A), S(−)-Baclofen (B) and RS-Baclofen (C). All doses of the different forms of Baclofen were administered in a random order. Rats received first the R(+)-Baclofen, then the S(−)-Baclofen and finally the RS-Baclofen. A significant dose and sex effect was found only for the R(+)-Baclofen. Data have been normalized so that the 100% represents the level of ethanol self-administration during the last session of the 5 consecutive sessions (days) of habituation (saline but no baclofen injection).