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. 2023 Mar 16;14:1146848. doi: 10.3389/fphar.2023.1146848

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Copyright © 2023 Jeanblanc, Sauton, Houdant, Fernandez Rodriguez, de Sousa, Jeanblanc, Bodeau, Labat, Soichot, Vorspan and Naassila.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blood RS(±)-Baclofen concentrations and correlation to its efficacy. (A) Blood samples were collected 30 and 90 min after the i.p. administration of a dose of 1.5 mg/kg of RS(±)-Baclofen. Results are expressed as Mean ± SEM blood Baclofen concentration in ng/mL. ***p < 0.001 vs. 30-min data within each sex. (B,C) Correlations between blood Baclofen concentration and efficacy in reducing alcohol operant self-administration in males (B) and females (C). Blood Baclofen concentrations are expressed in ng/mL. Positive variations indicate an efficacy in reducing self-administration, negative numbers indicate opposite effect, meaning an increase in alcohol self-administration. For (A–C) males n = 14; females n = 13.