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. 2023 Mar 16;14:1146848. doi: 10.3389/fphar.2023.1146848

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Copyright © 2023 Jeanblanc, Sauton, Houdant, Fernandez Rodriguez, de Sousa, Jeanblanc, Bodeau, Labat, Soichot, Vorspan and Naassila.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolism of baclofen’s enantiomers in naïve males and female rats. The 3 Baclofen forms were i.p. injected randomly at the dose of 1.5 mg/kg and blood was collected 30 and 240 min after the administration. HPLC analysis was used to analyze the concentration of the enantiomers (A–C), and the metabolite 3-(4-Chlorophenyl)-4-hydroxybutyric acid (D–F). The ratio metabolite over enantiomers concentrations was then calculated (G–I). Results are expressed as Mean ± SEM of blood concentrations in ng/mL. For (A,D,G) males n = 5; females n = 10. For (B,E,H) males n = 8; females n = 9. For (C,F,I) males n = 6; females n = 9. For clarity purpose we did not depict the significant differences we found for all the comparisons between the 2 timepoints within each sex group. *p < 0.05, **p < 0.01 and ***p < 0.001.