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. 2023 Mar 16;14:1156629. doi: 10.3389/fphar.2023.1156629

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Copyright © 2023 Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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N6-methyladenosine (m6A) methylation dynamically regulates mRNA through multiple pathways. M6A regulatory proteins include m6A methyltransferases (m6A writers), m6A demethylases (m6A erasers), and m6A recognition proteins (m6A readers). The writers act as methyltransferase including Mettl3/14 and WTAP. The erasers mediate demethylation modifications, like FTP and ALKBH5. M6A readers recognize information about mRNA methylation and are involved in downstream mRNA translation, degradation, and other behaviors, such as YTHDF1/2 and TYHDC1.