TABLE 1.

The role of Mettl3 in cervical cancer.

Cancer species	Expression	Biological function	Mechanism	Reference
cervical cancer	Up	Promote cell migration, chemotaxis, and tumor growth, influence cytokines	Associated with HPV infection status, immune checkpoint molecules, and immune infiltration	Yu et al. (2022)
	Up	Promote tumor growth, metastasis and chemoresistance	Regulate glycolysis in cervical cancer cells by enhancing the mRNA stability of PDK4	Li et al. (2020)
	Up	Promote cell proliferation and migration	Downregulate p21 through FOXD2-AS1/LSD1/P21Z axis	Ji et al. (2021)
	Up	Promote cell proliferation and warburg effect	Recruit YTHDF1 to enhance the stability of HK2 mRNA	Wang et al. (2020d)
	Down	Increase cisplatin chemosensitivity, inhibit the viability and proliferation	Decrease the activity of RAGE	Li et al. (2021a)
	Up	Promote cell proliferation and metastasis and inhibit apoptosis and autophagy	Promote the translation of TXNDC5 mRNA	Du et al. (2022)
	Up	Associated with poor prognosis, and promote cell proliferation	Increase mRNA stability of oncogene RAB2B via GF2BP3-dependent pathway	Hu et al. (2020)
	Up	Independent indicators for poor prognosis	The expression of Mettl3 was positively related with iASPP	Wu et al. (2020)
	Up	Promote tumor development, and associated with poor outcomes	The level of Mettl3 is positively linked to the number of CD33+ MDSC	Ni et al. (2020)
	Up	Confer cancer cell tolerance to hypoxic stress, promoting cell survival and adaptation	Enhance cytoprotective autophagy and tolerance to hypoxic environments by increasing the mRNA stability of DARS and acting on the DARS-AS1/ATG5/ATG3 axis	Shen et al. (2022a)
	Up	Facilitate cell cycle progression, promote cell proliferation in vitro and enhance tumorigenicity in vivo	Accelerated the translation of CDC25B mRNA through YTHDF1-dependent m6A modification	Li et al. (2022)
	Up	Promote tumor growth	Hinder miR-193b maturation, which inhibits tumorigenesis of cervical cancer cells through CCND1 targeting	Huang et al. (2021b)
	Up	Promote tumor growth, migration and aggressiveness	Mettl3 interacts with IGF2BP3 to promote the mRNA stability of ACIN1	Su et al. (2022)
	Up	Associated with poor prognosis	Negatively correlated with the expression of PD-L1	Ji et al. (2022)
	Up	Promote tumor growth in vivo and cell proliferation, migration, and invasion in vitro	Promote the sequestration of miR-647 by ZAFS1 through the regulation of RNA-RNA interactions	Yang et al. (2020)