TABLE 2.

The role of Mettl3 in ovarian cancer.

Cancer species	Expression	Biological function	Mechanism	Reference
ovarian cancer	Up	Promote cell proliferation, migration, and invasion, and inhibit apoptosis	Promote miR-126-5p maturation by increasing the degree of m6A modification of pri-miR-126-5pmRNA and facilitate tumorigenesis and migration through the PTEN/PI3K/AKT3/mTOR axis	Bi et al. (2021a)
	Up	Promote proliferation, migration, invasion, and inhibition of apoptosis	Promote the conversion of pre-miR-1246 to mature miR-1246 mRNA, and miR-1246 targets CCNG2 and inhibits its expression	Bi et al. (2021b)
	Up	Promote cell proliferation and migration, and inhibit cell apoptosis	As an independent factor affecting ovarian cancer prognosis and correlated with ovarian cancer-associated oncogene m6A enrichment	Ma et al. (2020)
	Up	Promote migration and invasion	Stabilize TRPC3 mRNA expression via m6A modification	Shen et al. (2022b)
	Up	Promote cell proliferation, tumor growth, and invasion	Stimulate AXL translation and EMT	Hua et al. (2018)
	Up	Inhibit cell apoptosis and promote the cell cycle	Increase the level of KRT8, and decrease the level of FAS	Yang et al. (2022)
	Up	Inhibit cell apoptosis and promote invasion	Increase activation of the AKT signaling pathway and the expression of the downstream effector Cyclin D1	Liang et al. (2020b)
	Up	Promote cell growth and development, metastasis and invasion, and weaken cisplatin sensitivity	Mettl3/YTHDF2 axis represses tumor suppressor gene IFFO1 expression and promotes mRNA degradation	Zhang et al. (2023)