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. 2023 Mar 16;11:1152207. doi: 10.3389/fbioe.2023.1152207

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Copyright © 2023 Tilotta, Vadalà, Ambrosio, Cicione, Di Giacomo, Russo, Papalia and Denaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSC-derived secretome enhanced hNPC viability and reduced cell death. The LIVE/DEAD assay showed that both BM-MSCsec and ADSCsec significantly increased cell viability compared to the control group (A). Following IL-1β pretreatment, BM-MSCsec significantly rescued hNPC vitality compared to cells treated with IL-1β alone (B). (C) BM-MSCsec and ADSCsec treatment did not substantially impact on cell death. (D) After IL-1β pretreatment, BM-MSCsec significantly reduced the number of dead cells compared to hNPCs treated with IL-1β alone. Results were normalized to the control group and expressed as percent variation. *p < 0.05, **p < 0.01.