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. 2023 Mar 16;11:1152207. doi: 10.3389/fbioe.2023.1152207

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Copyright © 2023 Tilotta, Vadalà, Ambrosio, Cicione, Di Giacomo, Russo, Papalia and Denaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSC-derived secretome increased hNPC proliferation. (A) Both BM-MSCsec and ADSCsec significantly increased hNPC content at 14 days of culture. (B) After IL-1β pretreatment, cell numerosity was aberrantly increased at 7 and 14 days compared to the controls. Treatment with BM-MSCsec and ADSCsec resulted in a substantial increase of cell content compared to the control group, while being lower than the group treated with IL-1β. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ^# p < 0.05 compared to IL-1β.