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. 2023 Mar 16;11:1152207. doi: 10.3389/fbioe.2023.1152207

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Copyright © 2023 Tilotta, Vadalà, Ambrosio, Cicione, Di Giacomo, Russo, Papalia and Denaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BM-MSCsec increased GAG content in treated hNPCs. (A) GAG/DNA ratio in hNPCs after MSC secretome treatment demonstrated a significant increase in the group treated with BM-MSCsec. (B) Following IL-1β pretreatment, both BM-MSCsec and ADSCsec demonstrated to rescue GAG/DNA levels compared to the group treated with IL-1β only. Data are expressed as GAG/DNA ratio percent variation between the control and experimental groups. *p < 0.05, **p < 0.01.