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BM-MSCsec improved hNPC ECM and catabolic marker gene expression. hNPCs treated with BM-MSCsec demonstrated a higher expression of ACAN (A) and SOX9 (B) genes, while significantly reducing IL6 (C), ADAMTS5 (D) and MMP13 (E) gene expression. Conversely, no significant differences were found in the group treated with ADSCsec. Results were normalized based on GAPDH expression and calculated as fold change compared to the controls. **p < 0.01.
