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. 2023 Mar 16;11:1152207. doi: 10.3389/fbioe.2023.1152207

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Copyright © 2023 Tilotta, Vadalà, Ambrosio, Cicione, Di Giacomo, Russo, Papalia and Denaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSC secretomes differentially impacted on hNPC ECM and catabolic marker gene expression following IL-1β pretreatment. BM-MSCsec significantly rescued the expression of ACAN (A) and SOX9 (B) genes, while significantly reducing IL6 (C), ADAMTS5 (D) and MMP13 (E) gene expression following IL-1β pretreatment. Conversely, ADSCsec significantly reduced the expression of both ACAN and SOX9, while increasing catabolic marker levels. Results were normalized based on GAPDH expression and calculated as fold change compared to the controls. *p < 0.05, **p < 0.01, ***p < 0.001, ^# p < 0.05 compared to IL-1β.