Table 2.
Pathway analysis of significantly conserved genes
| Pathway name | Category | FDR |
|---|---|---|
| Antigen presentation: folding, assembly and peptide loading of class I MHC | Immune presentation | 2.79E-14 |
| ER-phagosome pathway | Immune presentation | 2.79E-14 |
| Endosomal/vacuolar pathway | Immune presentation | 2.79E-14 |
| Antigen processing-cross presentation | Immune presentation | 2.79E-14 |
| Interferon signaling | Immune signaling | 2.79E-14 |
| Interferon gamma signaling | Immune signaling | 2.79E-14 |
| Interferon alpha/beta signaling | Immune signaling | 2.79E-14 |
| Class I MHC mediated antigen processing and presentation | Immune presentation | 4.65E-09 |
| Non-sense-mediated decay (NMD) | RNA metabolism | 1.46E-04 |
| NMD enhanced by the exon junction complex (EJC) | RNA metabolism | 1.46E-04 |
| Immunoregulatory interactions between a lymphoid and a non-lymphoid cell | Immune signaling | 2.02E-04 |
| Cytokine signaling in immune system | Immune signaling | 2.37E-04 |
| NMD independent of the EJC | RNA metabolism | 5.45E-04 |
| Eukaryotic translation elongation | Protein translation | 6.21E-04 |
| Metabolism of RNA | RNA metabolism | 9.77E-04 |
| Peptide chain elongation | Protein translation | 0.001 |
| Response of EIF2AK4 (GCN2) to amino acid deficiency | Metabolism; signaling | 0.001 |
| GTP hydrolysis and joining of the 60S ribosomal subunit | Protein translation | 0.001 |
| L13a-mediated translational silencing of Ceruloplasmin expression | Protein translation | 0.001 |
| Eukaryotic translation initiation | Protein translation | 0.001 |
| Cap-dependent translation initiation | Protein translation | 0.001 |
| Regulation of expression of SLITs and ROBOs | Transcription; signaling | 0.001 |
| Eukaryotic translation termination | Protein translation | 0.004 |
| Cellular response to starvation | Signaling | 0.006 |
| Formation of a pool of free 40S subunits | Protein translation | 0.009 |
| Translocation of ZAP-70 to immunological synapse | Immune presentation | 0.014 |
| SRP-dependent cotranslational protein targeting to membrane | Protein translation | 0.015 |
| Phosphorylation of CD3 and TCR zeta chains | Immune presentation | 0.026 |
| PD-1 signaling | Immune signaling | 0.026 |
| Selenocysteine synthesis | Amino acid metabolism | 0.040 |
| Folding of actin by CCT/TriC | Protein folding | 0.042 |
| Signaling by ROBO receptors | Signaling | 0.049 |
| Viral mRNA translation | Translation; disease | 0.049 |
Note: Pathway analysis was performed by taking the list of genes which were significantly conserved at a level of the 95th percentile in the adjusted bootstrap, and feeding this list into Reactome’s online pathway enrichment tool. Resulting pathways were selected based on FDR at a significance level alpha = 0.05, here reporting pathway names, category and FDR values. Detailed results including significant gene names and gene hits in each pathway are included in Supplementary Table S2.