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. 2023 Mar 16;17:1086895. doi: 10.3389/fncel.2023.1086895

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Copyright © 2023 Diab, Pilotto and Saxena.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RAB proteins involved in different steps of the autophagy-lysosome pathway (ALP). Schematic representation of RAB GTPases and their binding partners in the ALP. RAB1, RAB6, and RAB4 are important for the formation of the pre-autophagosomal structure (PAS) providing membrane sources for the initiation of the autophagy pathway, while RAB5, RAB30, RAB33 are involved in autophagosome maturation together with RAB7, which is also involved in the fusion of the autophagosomes with late endosomes.