TABLE 1.

List of RAB proteins involved in the autosomal-lysosomal pathway (ALP).

RAB	Autophagy stage	C9ORF72 interaction	References
RAB1A	Autophagy activation and induction	+	Webster et al., 2016
RAB39A		Unknown	Niu et al., 2020
RAB24		Unknown	Munafó and Colombo, 2002
RAB37	Initiation of pre-autophagosome formation	Unknown	Sheng et al., 2017
RAB7	Lysosome reformation during autophagy	+	Yu et al., 2010; Farg et al., 2017
RAB1A	Autophagosome formation	+	Carlos Martín Zoppino et al., 2010; Hutagalung and Novick, 2011; Farg et al., 2017
RAB1B		+	Winslow et al., 2010; Hutagalung and Novick, 2011; Farg et al., 2017
RAB4		Unknown	Hutagalung and Novick, 2011; Talaber et al., 2014
RAB5		+	Ravikumar et al., 2008; Hutagalung and Novick, 2011; Farg et al., 2017
RAB7		+	Yamaguchi et al., 2009; Hutagalung and Novick, 2011; Farg et al., 2017
RAB9A		Unknown	Hutagalung and Novick, 2011; Nozawa et al., 2012; Yan et al., 2013
RAB10		Unknown	Limanaqi et al., 2018
RAB11		+	Fader et al., 2007; Morvan et al., 2009; Hutagalung and Novick, 2011
RAB32		Unknown	Hirota and Tanaka, 2009; Hutagalung and Novick, 2011; Wang C. et al., 2012
RAB33B			Itoh et al., 2008; Hutagalung and Novick, 2011
RAB7	Autophagosome maturation	+	Hutagalung and Novick, 2011; Hyttinen et al., 2013; Farg et al., 2017
RAB8B		+	Hutagalung and Novick, 2011; Pilli et al., 2012; Sellier et al., 2016
RAB24		Unknown	Ao et al., 2014
RAB9		Unknown	Nozawa et al., 2012
RAB10		Unknown	Limanaqi et al., 2018
RAB11		+	Fader et al., 2007; Farg et al., 2017
RAB33B		Unknown	Itoh et al., 2011
RAB39B		+	Pilli et al., 2012; Sellier et al., 2016
RAB8A	PINK-dependent mitophagy	+	Lai et al., 2015; Sullivan et al., 2016
RAB8B		+	Ginns et al., 2014
RAB13		Unknown	Lai et al., 2015
RAB5	Links SVs to pre-autophagosomal structures	Unknown	Limanaqi et al., 2018
RAB26		Unknown	Binotti et al., 2015
RAB35		+	Wu et al., 2011; Limanaqi et al., 2018

Further, the direct interaction of C9ORF72 with various RAB proteins are indicated. Note the interaction/involvement of C9ORF72 with RAB proteins at multiple levels of the ALP, which are indicated by a (+) sign. SVs, synaptic vesicles.