Skip to main content
. 2023 Mar 16;17:1105530. doi: 10.3389/fnins.2023.1105530

FIGURE 2.

FIGURE 2

Upregulation of CXCL12 in the spinal cord can effectively reduce the clinical scores and demyelination of experimental autoimmune encephalomyelitis (EAE). (A) EAE was induced in Lewis rats (n = 15 in each group). The clinical scores were determined as described in the Methods section. The horizontal bars show the stages of EAE progression (the initial stage was 2–4 days, the peak stage was 12–14 days, and the recovery stage was 38–40 days). The rats were sacrificed for immunofluorescence detection at the each stage. (B) Representative images of Luxol fast blue periodic acid-Schiff (LFB-PAS) staining in the spinal cord at three stages in all three groups. The bar in the lower right represents 50 μm. (C) Demyelination score based on LFB-PAS staining in spinal cord. Data presented as the mean ± SEM. “*” represents value of P < 0.05, “**” represents value of P < 0.01, “***” represents value of P < 0.001 by 2-tailed unpaired Student’s t-test or 1-way ANOVA.