Mean WMH volume differences between Amyloid negative, Tau negative (A-/T-) participants and participants with different pathology status: Amyloid positive, Tau negative (A+/T-; (p = 0.002, Cohen’s d = 0.5); Amyloid negative, Tau positive (A-/T+; (p = 0.02, Cohen’s d = 0.9); Amyloid positive, Tau positive (A+/T+; p = 0.007, Cohen’s d = 0.4).