Table 2.
Association of poly-Ala-FOXE1 isoforms with CH and TD.
| Polyalanine alleles frequencies in healthy subjects and CH patients | |||||
|---|---|---|---|---|---|
| FOXE1 | CH (n) | Healthy Subjects (n) | Fisher’s exact test | Relative Risk (95% CI) |
Odds ratio (95% CI) |
| Ala-14/14 | 157 | 466 | – | – | – |
| Ala-14/16 | 61 | 368 | < 0.0001 | 1.772 (1.359 to 2.323) | 2.031 (1.453 to 2.865) |
| Ala-16/16 | 70 | 550 | < 0.0001 | 2.232 (1.727 to 2.893) | 2.645 (1.928 to 3.625) |
| Ala-14/16 and 16/16 | 131 | 918 | < 0.0001 | 2.018 (1.636 to 2.487) | 2.360 (1.809 to 3.080) |
| Polyalanine alleles frequencies in TD and GIS patients | |||||
| TD (n) | GIS (n) | Fisher’s exact test | Relative Risk (95% CI) |
Odds ratio (95% CI) |
|
| Ala-14/14 | 54 | 72 | – | – | – |
| Ala-14/16 | 11 | 30 | 0.096 | 1.597 (0.970 to 2.821) | 2.037 (0.895 to 4.926) |
| Ala-16/16 | 8 | 42 | 0.0008 | 2.679 (1.445 to 5.282) | 3.909 (1.639 to 10.448) |
| Ala-14/16 and 16/16 | 19 | 72 | 0.0008 | 2.053 (1.334 to 3.240) | 2.829 (1.479 to 5.580) |
CH, congenital hypothyroidism; HS, Healthy Subjects; TD, Thyroid Disgenesys; GIS, gland-in-situ.