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. 2023 Mar 16;10:1070734. doi: 10.3389/fmed.2023.1070734

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Copyright © 2023 Nanthakumar, Meng and Newburg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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α1,2/3-fucosyltransferase (FucT) activity and fut2 mRNA in conventionally raised (CONV), bacteria-depleted (BD), and bacteria-repleted (XBD) mice. (A) Black Swiss, (B) C3H, (C,D) C57/B6. C3H/HeJ is isogenic strain of C3H/Ouj, but with an inactive TLR4 point mutation. The wild-type C57/B6 mice and TLR2^−/− exhibited normal colonization dependent induction of FucT activity and fut2 mRNA. TLR4^−/− and MyD88^−/− mutants displayed low expression FucT activity and fut2 mRNA, irrespective of colonization status. Thus, TLR4-mediated signaling is necessary for bacterial induction of fucosyltransferase expression. Data are mean ± SEM, n = 6–8 (*p < 0.01; **p < 0.001).