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. 2023 Mar 16;17:1137957. doi: 10.3389/fnbeh.2023.1137957

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Copyright © 2023 Kibret, Canseco-Alba, Onaivi and Engidawork.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of the microbiota-gut-brain axis in CNS disorders. There is a bidirectional communication between the gut microbiota and the brain through the vagus nerve. Gut dysbiosis may play a crucial role in neural development, neurotransmission, neuroinflammation, and changes in neurotransmitter function, which in turn contribute to the pathogenesis of neuropsychiatric, and neurodegenerative diseases. Cannabinoid ligands targeting central cannabinoid receptors might be used in the treatment of Parkinson’s disease, drug addiction, or schizophrenia. CBRs, cannabinoid receptors.