Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 21;17(4):611–628. doi: 10.1002/1878-0261.13373

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig. 4 — APOE+CTSZ+TAM upregulated GLUL and glutamate‐to‐glutamine metabolic flux. (A, B) SLC1A3 and GLUL expression among cell subtypes in CRC‐MMRp samples (A) and CRC‐MMRd samples (B). ***P < 0.001, Kruskal–Wallis test. The mean gene expression is marked in the bar graph and vertical lines indicate the maximum and minimum values of the gene expression. (C, D) SLC1A3 and GLUL expression in macrophage divided from tumor and normal samples in CRC‐MMRp samples (n = 29 in tumor samples, n = 29 in normal samples) (C) and CRC‐MMRd samples (n = 35 in tumor samples, n = 35 in normal samples) (D). (E, F) GLUL expression among different histologic grade samples and node status in CRC‐MMRp samples (E) and CRC‐MMRd samples (F). (G, H) M_48 score among different histologic grade samples and node status in CRC‐MMRp samples (G) and CRC‐MMRd samples (H). (I, J) Glutamine accumulation value among different histologic grade samples and node status in CRC‐MMRp samples (I) and CRC‐MMRd samples (J). ***P < 0.001, unpaired one‐sided Wilcoxon test. CRC‐MMRp tumor sample (n = 29), CRC‐MMRd sample (n = 35), high‐grade CRC‐MMRp tumor sample (n = 4), low‐grade CRC‐MMRp tumor sample (n = 25), high‐grade CRC‐MMRd tumor sample (n = 9), low‐grade CRC‐MMRd tumor sample (n = 26), N0 CRC‐MMRp tumor sample (n = 12), N1&2&3‐grade CRC‐MMRp tumor sample (n = 17), N0 CRC‐MMRd tumor sample (n = 23), and N1&2&3‐grade CRC‐MMRd tumor sample (n = 12). Mono, monocyte; DC, dendritic cell; NK, natural killer; Tfh, follicular helper T cell; Fib, fibroblast; End, endothelial cell; B, B cell; Mye, myeloid cells; Epi, epithelial cells.