Fig. 2.

Mutational spectrum of 95 genes in Vietnamese breast cancer women. (A) The number of somatic mutations identified per patient was significantly higher in the HR− HER2+ compared to the HR+ groups. (B) The mutation burden was significantly lower in stage I compared to stage II and III. (C) Pie chart showing the distribution of mutation classes identified in 95 genes. (D) The top 25 significantly mutated genes in the cohort. (E) Frequency of top highly mutated genes in breast cancer was compared between our cohort and published datasets of Caucasian and Asian cohorts. (F) Pairwise analysis identified oncogenic alternations significantly associated with different subtypes. Genes in green color were significantly more altered in a particular group compared to the rest while genes in black color were significantly less altered. HR, Hormone receptors; HER2, Human epidermal growth factor receptor 2. *P < 0.05; Kruskal–Wallis and post hoc Dunn's test for (A) and (B); Fisher's exact test for (F). (A), (B): Boxplots with Tukey whiskers.