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. 2023 Mar 30;8(2):283–298. doi: 10.1089/can.2022.0011

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© Christopher D. Drummond-Main et al. 2023; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 5. — LPI, a GPR55 agonist, does not alter mPT and mtCl channel activity in acutely isolated rat brain mitochondria. (A) The threshold for calcium-induced mPT is not affected by LPI at concentrations ranging from 0.1 to 10 μM. Bar graph depicting mean±SEM of mPT threshold (n=3 rats per group). The y-axis indicates the amount of Ca²⁺ added to the mitochondrial suspension. One-way ANOVA [F(3, 8)=(0.6527), p=0.6033, NS]. (B) Representative recordings at +30 mV showing mitochondrial chloride channel activity before (top graph) and after 10 μM LPI (bottom graph). Channel activity was unaffected by 10 μM LPI (n=3 per group). Downward deflections indicate channel openings. GPR55, G-protein-coupled receptor 55; LPI, lysophosphatidylinositol.