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. 2023 Mar 30;8(2):283–298. doi: 10.1089/can.2022.0011

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© Christopher D. Drummond-Main et al. 2023; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 8. — CBD affects cellular viability. Representative photomicrographs (top panel) of HT22 cells after 24 h with media alone or the CBD dose range of 1–100 μM. Summary bar graph (bottom panel) indicating changes in cellular viability at 24 h after the treatment of diverse doses of CBD was expressed as a percentage of the control group. The administration of concentrations ranging from 100 nM to 1 μM CBD did not alter cell viability compared with control. CBD prominently produced neuronal cell death at concentrations >1 μM. A one-way ANOVA revealed a significant effect of CBD concentration on the viability of HT22 cells [F(5, 369)=(79.21), p<0.0001]. A Tukey post hoc multiple comparisons test revealed that concentrations of CBD >1 μM significantly decrease the viability of HT22 cells (p<0.0001) compared with the other groups. Data represent the mean±SEM. NS, ***p<0.001, and ****p<0.0001.