. 2023 Mar 28;40(7-8):693–705. doi: 10.1089/neu.2022.0267

Table 6.

Brain Regions in which Brain Biomarker Changes were Significantly Correlated with Changes in White Matter Integrity Before and After a Workout Session

Biomarker	Region and correlation^a with FA Δ (T-1)-T3^b		Region and correlation^a with MD Δ (T-1)-T3^c
Tau ΔT0-T1^d	Posterior CC: -0.68^f	Tapetum: -0.72^f	Left IFOC: -0.68^f Left ILF: -0.68^f
ΔT0-T2^e	Left OT: 0.65^f		Right Cing: -0.67^f Left IFOC: -0.67^f Left ILF: -0.68^f Left OR: -0.72^f	Left PRT: -0.72^f Left SLF: -0.71^f Left STR: -0.71^f Left UF: -0.65^f
NF-L ΔT0-T1^d	—		Posterior CC: 0.78^f Right CST: 0.67^f	Tapetum: 0.80^g
ΔT0-T2^e	—		Right SFOF: -0.71^f
GFAP ΔT0-T1^d	Right ATR: 0.67^f	Left IFOC: 0.67^f	—
ΔT0-T2^e	Left OT: 0.73^f		Right UF: -0.64^f
UCH-L1 ΔT0-T1^d	Right UF: -0.83^g		Right PTR: 0.74^f
ΔT0-T2^e	Posterior CC: -0.82^f	Right UF: -0.86^f	—

^{^a}

Spearman correlation coefficient; ^bChange in fractional anisotropy from 24 h before workout to 48 h after workout; ^cChange in mean diffusivity from 24 h before workout to 48 h after workout; ^dBiomarker change from immediately before workout to immediately after workout; ^eBiomarker change from immediately before workout to 45 min after workout; ^fp < 0.05, ^gp < 0.01.

Bold: Bonferonni-corrected p value <0.0013.

ATR, anterior thalamus radiation; CC, corpus callosum; CPT, corticopontine tract; Cing, cingulum; CST, corticospinal tract; ICP, inferior cerebellar peduncle; IFOC, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; ML, medial lemniscus; OR, optic radiation; OT, optic tract; PTR, posterior thalamus radiation; SCP, superior cerebellar peduncle; SFOF, superior fronto-occipital fasciculus; SLF, superior longitudinal fasciculus; STR, superior thalamus radiation; UF, uncinate fasciculus.