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. 2023 Mar 30;8(2):230–240. doi: 10.1089/can.2022.0130

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Copyright 2023, Mary Ann Liebert, Inc., publishers

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FIG. 2. — CBD inhibition of synaptic signaling. CBD inhibits hydrolysis of AEA and 2-AG in the postsynaptic terminal by competitively binding to FAAH and MAGL, respectively. AEA and 2-AG then activate CB1R and CB2R on the presynaptic terminal, leading to suppression of neurotransmitter release. CBD can also act on the TRPV1 receptor, desensitizing TRPV1 channels and increasing Ca²⁺ concentrations in the presynaptic neuron. Created with BioRender.com. CB1R, cannabinoid receptor type 1; CB2R, cannabinoid receptor type 2; MAGL, monoacylglycerol lipase; TRPV1, transient receptor potential of vanilloid subtype 1.