Table 3.
Characteristics of patients with and without anti-SARS-CoV-2-S IgG seroconversion.
| Seroconversion N (%) |
No seroconversion N (%) |
|
|---|---|---|
| Total | 74 (100.0) | 3 (100.0) |
| Median age, years (range) | 55.6 (23.8-86.3) | 56.9 (55.3-84.7) |
| Sex | ||
| Female | 36 (48.6) | 3 (100.0) |
| Male | 38 (51.4) | 0 |
| Charlson comorbidity index | ||
| 0 | 44 (59.5) | 2 (66.7) |
| 1-2 | 22 (29.7) | 1 (33.3) |
| ≥3 | 8 (10.8) | 0 |
| Severity of psoriasis | ||
| Moderate (Psoriasis Area and Severity Index <20) | 63 (85.1) | 3 (100.0) |
| Severe (Psoriasis Area and Severity Index ≥20) | 11 (14.9) | 0 (0.0) |
| Type of psoriasis treatment | ||
| Biologics | 64 (86.5) | 2 (66.7) |
| TNF-α inhibitor | 14 (18.9) | 2 (66.7) |
| Interleukin inhibitor | 50 (67.6) | 0 |
| Interleukin 12-/13 inhibitor | 8 (10.8) | 0 |
| Ustekinumab | 8 (10.8) | 0 |
| Interleukin 17A inhibitor | 21 (28.4) | 0 |
| Secukinumab | 5 (6.8) | 0 |
| Ixekizumab | 16 (21.6) | 0 |
| Interleukin 23 inhibitor | 21 (28.4) | 0 |
| Tildrakizumab | 9 (12.2) | 0 |
| Risankizumab | 2 (2.7) | 0 |
| Guselkumab | 10 (13.5) | 0 |
| Methotrexate 10-15 mg/week | 8 (10.8) | 1 (33.3) |
| Apremilast (Phosphodiesterase inhibitor) | 1 (1.4) | 0 |
| Dimethyl fumarate | 1 (1.4) | 0 |
| Immunosuppressive comedication for psoriasis | ||
| None | 70 (94.6) | 2 (66.7) |
| Prednisolon 5mg/daily | 1 (1.4) | 0 |
| Methotrexate | 3 (4.1) | 1 (33.3) |
| Methotrexate 5 mg/week | 1 (1.4) | 1 (33.3) |
| Methorexate 7.5 mg/week | 1 (1.4) | 0 |
| Methotrexate 10 mg/week | 1 (1.4) | 0 |
| Methotrexate as main posriasis treatment or comedication | ||
| Yes | 11 (14.9) | 2 (66.7) |
| No | 63 (85.1) | 1 (33.3) |
| Leukocytes (3.6-9.2/nL) | ||
| Median (range) | 7.3 (3.8-12.0) | 7.0 (5.8-8.1) |
| Decreased | 0 | |
| Within the normal range | 3 (100.0) | |
| Increased | 0 | |
| Not available | 6 (8.1) | 0 |
| Neutrophils (1.7-6.2/nL) | ||
| Median (range) | 4.4(2.2-8.5) | 4.5 (2.4-6.3) |
| Decreased | 0 | 0 |
| Within the normal range | 59 (79.7) | 2 (66.7) |
| Increased | 8 (10.8) | 1 (33.3) |
| Not available | 7 (9.5) | 0 |
| Lymphocytes (1.0-3.4/nL) | ||
| Median (range) | 1.8 (0.6-3.8) | 1.6 (0.9-2.8) |
| Decreased | 3 (4.1) | 1 (33.3) |
| Within the normal range | 58 (78.4) | 2 (66.7) |
| Increased | 6 (8.1) | 0 |
| Not available | 7 (9.5) | 0 |