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. 2023 Mar 16;14:1107438. doi: 10.3389/fimmu.2023.1107438

Table 3.

Characteristics of patients with and without anti-SARS-CoV-2-S IgG seroconversion.

Seroconversion
N (%)
No seroconversion
N (%)
Total 74 (100.0) 3 (100.0)
Median age, years (range) 55.6 (23.8-86.3) 56.9 (55.3-84.7)
Sex
 Female 36 (48.6) 3 (100.0)
 Male 38 (51.4) 0
Charlson comorbidity index
 0 44 (59.5) 2 (66.7)
 1-2 22 (29.7) 1 (33.3)
 ≥3 8 (10.8) 0
Severity of psoriasis
 Moderate (Psoriasis Area and Severity Index <20) 63 (85.1) 3 (100.0)
 Severe (Psoriasis Area and Severity Index ≥20) 11 (14.9) 0 (0.0)
Type of psoriasis treatment
 Biologics 64 (86.5) 2 (66.7)
  TNF-α inhibitor 14 (18.9) 2 (66.7)
  Interleukin inhibitor 50 (67.6) 0
   Interleukin 12-/13 inhibitor 8 (10.8) 0
    Ustekinumab 8 (10.8) 0
  Interleukin 17A inhibitor 21 (28.4) 0
    Secukinumab 5 (6.8) 0
    Ixekizumab 16 (21.6) 0
  Interleukin 23 inhibitor 21 (28.4) 0
    Tildrakizumab 9 (12.2) 0
    Risankizumab 2 (2.7) 0
    Guselkumab 10 (13.5) 0
 Methotrexate 10-15 mg/week 8 (10.8) 1 (33.3)
 Apremilast (Phosphodiesterase inhibitor) 1 (1.4) 0
 Dimethyl fumarate 1 (1.4) 0
Immunosuppressive comedication for psoriasis
 None 70 (94.6) 2 (66.7)
 Prednisolon 5mg/daily 1 (1.4) 0
 Methotrexate 3 (4.1) 1 (33.3)
 Methotrexate 5 mg/week 1 (1.4) 1 (33.3)
 Methorexate 7.5 mg/week 1 (1.4) 0
 Methotrexate 10 mg/week 1 (1.4) 0
Methotrexate as main posriasis treatment or comedication
 Yes 11 (14.9) 2 (66.7)
 No 63 (85.1) 1 (33.3)
Leukocytes (3.6-9.2/nL)
 Median (range) 7.3 (3.8-12.0) 7.0 (5.8-8.1)
 Decreased 0
 Within the normal range 3 (100.0)
 Increased 0
 Not available 6 (8.1) 0
Neutrophils (1.7-6.2/nL)
 Median (range) 4.4(2.2-8.5) 4.5 (2.4-6.3)
 Decreased 0 0
 Within the normal range 59 (79.7) 2 (66.7)
 Increased 8 (10.8) 1 (33.3)
 Not available 7 (9.5) 0
Lymphocytes (1.0-3.4/nL)
 Median (range) 1.8 (0.6-3.8) 1.6 (0.9-2.8)
 Decreased 3 (4.1) 1 (33.3)
 Within the normal range 58 (78.4) 2 (66.7)
 Increased 6 (8.1) 0
 Not available 7 (9.5) 0