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. 2023 Jan 31;14:1091040. doi: 10.3389/fendo.2023.1091040

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Copyright © 2023 Cao, Tan, Yan, Shen, Hua, Shao and Yao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SG significantly modulated the colonic transcriptome. (A) Volcano plots shows differentially expressed genes (DEGs) of colon between SHAM and SG groups. Blue dots and red dots represent significantly down-regulated and up-regulated genes, respectively (Log2 Fold change >1, Bonferroni-adjusted P < 0.05). (B) Enrichment analysis of Gene Ontology (GO) including Biological Process (BP), Molecular Function (MF), and Cell Component (CC) based on the DEGs between SHAM vs SG. (C) Volcano plots shows DEGs of colon between antibiotics-treated SG and SHAM groups. Blue dots and red dots represent significantly down-regulated and up-regulated genes, respectively (Log2 Fold change >1, Bonferroni-adjusted P < 0.05). (D) Enrichment analysis of GO based on the DEGs between SHAM-ABX vs SG-ABX. n = 6–8/group. SHAM, sham surgery; SG, sleeve gastrectomy; ABX, antibiotics.