Table 3.

Cox proportional hazards regression for disability-free survival of participants with and without metabolic syndrome (ACC/AHA 2018) according to Fried phenotype and Frailty Index

MetS by Fried Phenotype	Model 1	Model 2
	HR (95% CI)	HR (95% CI)
	(n =18,264; DFS loss=1,736)	(n=17,142; DFS loss=1,656)
No MetS, Non-frail (n= 5,675)	Reference	Reference
No MetS, Pre-frail (n= 3,322)	2.28 (1.98, 2.61)	1.68 (1.45, 1.94)
No MetS, Frail (n= 152)	5.45 (4.00, 7.41)	2.65 (1.92, 3.66)
MetS, Non-frail (n= 5,085)	0.98 (0.84, 1.15)	0.96 (0.82, 1.13)
MetS, Pre-frail (n= 3,793)	2.19 (1.91, 2.51)	1.70 (1.47, 1.96)
MetS, Frail (n= 237)	5.49 (4.23, 7.11)	3.02 (2.29, 3.98)
MetS by Frailty Index	(n =18,262; DFS loss=1,735)	(n=17,140; DFS loss=1,655)
No MetS, Non-frail (n= 5,886)	Reference	Reference
No MetS, Pre-frail (n= 2,885)	2.34 (2.02, 2.69)	1.90 (1.63, 2.21)
No MetS, Frail (n= 377)	5.77 (4.66, 7.14)	4.05 (3.22, 5.11)
MetS, Non-frail (n= 3,501)	0.94 (0.79, 1.12)	1.00 (0.84, 1.19)
MetS, Pre-frail (n= 4,531)	1.63 (1.42, 1.87)	1.50 (1.29, 1.74)
MetS, Frail (n= 1,082)	4.19 (3.55, 4.93)	3.17 (2.64, 3.81)

Abbreviations: HR: Hazard Ratios; CI: Confidence Intervals; DFS: disability-free survival; Model 1: Unadjusted analysis; Model 2: Adjusted for age, gender, ethno-racial origin, education, smoking history, alcohol intake and chronic conditions/morbidities (chronic kidney disease, depression, previous cancer history).