Table 2.
Representative studies on lymph node metastasis patterns in EC
| Author (year) | Study layout | Country | Histology | Number of study participants | Details |
|---|---|---|---|---|---|
| Takeuchi (2009) | Prospective interventional study | Japan | SCC | 75 | The distribution of SLN in cT1-2N0M0 was described |
| Akutsu (2016) | Observational study using prospectively collected data | Japan | SCC | 211 | In cT1N0, the distribution of overall and initial LN metastases was assessed |
| Gertler (2014) | Retrospective research | Germany | SCC, AC, GC | 793 | Evaluated the prevalence and localization of LN metastasis in pT1 |
| Hagens (2020) | Systematic review | NA | SCC, AC | 8952 | Described the prevalence of LN metastases per histologic subtype and primary tumor location |
| Kurokawa (2019) | Prospective interventional study | Japan | SCC, AC | 371 | Evaluated the optimal extent of LN dissection for EGJ tumors |
SCC, squamous cell carcinoma; AC, adenocarcinoma; LN, lymph node; GC, gastric cancer; EGJ, esophagogastric junction; SLN, sentinel LN; EC, esophageal cancer.