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. 2023 Feb 28;11(5):197. doi: 10.21037/atm-22-2204

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2023 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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IMD-0354 attenuates oxidative injury and exerts antioxidative effects in the retina of diabetic rats. (A-C) Levels of SOD, GSH-Px, CAT, in the retina were remarkably lower in the diabetic group compared to the non-diabetic control group. Treatment with consecutive IMD-0354 injection for 6 weeks led to significant increases in GSH-Px, SOD and CAT levels. (D) MDA levels were significantly higher in the diabetic group compared to the non-diabetic control group. Administration of IMD-0354 induced a significant drop of the MDA levels in diabetic rats. (B-D) Data are shown as the mean ± SD (***, P<0.001; ^##, P<0.01; ^#, P<0.05). SOD, superoxide dismutase; GSH-Px, glutathione peroxidase; CAT, catalase; MDA, malonic dialdehyde; SD, standard deviation.