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. 2023 Feb 28;11(5):197. doi: 10.21037/atm-22-2204

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2023 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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IMD-0354 alleviates RGC loss in the retina of diabetic rats. Density of RGCs in the retina of diabetic rats was evaluated following Brn3a stain. (A) In the diabetes group, RGC density significantly decreased in inner retinal layers compared to the control group. After consecutive injection with IMD-0354 for 6 weeks, the rates of RGC loss in the retina of diabetic rats were significantly alleviated. (B) Quantitative analysis of Brn3a‑positive cells in the retina of diabetic rats treated with or without IMD-0354. The number of activated microglia were measured in areas of approximately the same distances of 1/6, 3/6, and 5/6 retinal radius from the optic disc in each quadrant (each piece of the retina was calculated four times at each distance under a fluorescent microscope). Data are shown as the mean ± SD. Scale bar =50 µm (***, P<0.001; ^#, P<0.05). RGC, retinal ganglion cell; SD, standard deviation.