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. 2023 Feb 28;11(5):197. doi: 10.21037/atm-22-2204

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2023 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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IMD-0354 reverses nuclear translocation of NF-κB-p65 in microglia in a high glucose environment. (A-F) Western blot analysis showed that high glucose promoted NF-κB-p65 expression and its nuclear translocation in microglia. Inhibition of IKK2 by IMD-0354 downregulated the expression of NF-κB-p65 and blocked its nuclear translocation (E) under high glucose conditions, whereas the cytoplasmic levels of NF-κB-p65 were unaffected (F). Data are shown as the mean ± SD (****, P<0.0001; ***^/###, P<0.001; ^##, P<0.01). HG, high glucose; NF-κB-p65, nuclear factor κB-p65; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; SD, standard deviation.