Table 3. BBB Permeability of 10b Determined Using PAMPA–BBB Assay.
| compound | λmax (nm) | Pe × 10–6 cm/s ± SD | prediction of CNS permeation |
|---|---|---|---|
| 10b | 261 | 5.68 ± 1.1 | CNS+ |
| donepezil | 270 | 13.32 ± 1.82 | CNS+ |
| theophylline | 272 | 1.22 ± 1.38 | CNS– |
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