Table 2. Antibacterial Activity of 1 and Its Derivatives as well as the Known Drugsa.
| |
MIC (μg/mL) |
||||||
|---|---|---|---|---|---|---|---|
| strains | 1 | 5 | 6 | 7 | VCM | LZD | |
| Staphylococcus aureus | ATCC6538P | 0.125 | 0.5 | 1 | 2 | 1 | 1 |
| Staphylococcus aureus | ATCC 19636 | 0.063 | 0.25 | 1 | 2 | 1 | 1 |
| Staphylococcus aureus | ISP217 | 0.063 | 0.125 | 0.5 | 0.5 | 1 | 1 |
| Staphylococcus aureus | KUB854 | 0.125 | 0.25 | 1 | 2 | 1 | 2 |
| Staphylococcus aureus | KUB855 | 0.125 | 0.25 | 0.5 | 1 | 0.5 | 1 |
| Staphylococcus aureus | KUB856 | 0.125 | 0.5 | 1 | 2 | 1 | 2 |
| Staphylococcus aureus | ATCC700699 | 0.063 | 0.125 | 0.5 | 1 | 8 | 1 |
| Staphylococcus aureus | KUB877 | 0.125 | 0.25 | 1 | 2 | 1 | 16 |
| Staphylococcus epidermidis | KUB795 | 0.25 | 0.5 | 2 | 2 | 1 | 1 |
| Kocuria rhizophila | ATCC9341 | 0.063 | 0.125 | 0.5 | 0.125 | 0.5 | 1 |
| Enterococcus faecalis | ATCC29212 | 0.063 | 0.063 | 0.25 | 0.25 | 4 | 1 |
| Enterococcus faecalis | NCTC12201 | 0.063 | 0.125 | 0.25 | 0.25 | >64 | 1 |
| Enterococcus faecalis | KUB7012 | 0.016 | 0.063 | 0.25 | 0.016 | >64 | 1 |
| Enterococcus faecium | NCTC12204 | 0.063 | 0.125 | 0.5 | 0.25 | >64 | 1 |
| Enterococcus faecium | KUB7013 | 0.031 | 0.125 | 0.5 | 0.125 | >64 | 2 |
| Enterococcus gallinarum | KUB7014 | 0.063 | 0.031 | 0.25 | 0.25 | 8 | 1 |
| Escherichia coli | NIHJ JC-2 | >8 | >8 | >8 | >8 | >64 | >64 |
| Citrobacter freundii | ATCC8090 | >8 | >8 | >8 | >8 | >64 | >64 |
| Klebsiella pneumoniae | NCTC9632 | >8 | >8 | >8 | >8 | >64 | >64 |
| Klebsiella aerogenes | NCTC10006 | >8 | >8 | >8 | >8 | >64 | >64 |
| Proteus vulgaris | ATCC8427 | >8 | >8 | >8 | >8 | >64 | 16 |
| Morganella morganii | IID 602 | >8 | >8 | >8 | >8 | >64 | >64 |
| Serratia marcescens | IFO12648 | >8 | >8 | >8 | >8 | >64 | >64 |
| Enterobacter cloacae | IFO13535 | >8 | >8 | >8 | >8 | >64 | >64 |
| Pseudomonas aeruginosa | 46001 | >8 | >8 | >8 | >8 | >64 | >64 |
| Pseudomonas aeruginosa | E-2 | >8 | >8 | >8 | >8 | >64 | >64 |
| Acinetobacter calcoaceticus | IFO12552 | >8 | >8 | >8 | >8 | >64 | >64 |
a
Abbreviations: VCM, vancomycin; LZD, linezolid.