Table 1. Composition of Various Curcumin Formulations That Are Tested Clinicallya.
| curcumin formulation | composition | ref |
|---|---|---|
| First-Generation Formulation | ||
| active ingredients formulated as soft gel capsules | fish oil 250 mg, phosphatidyl choline concentrated sunflower oil 150 mg, silymarin 75 mg, choline bitartrate 35 mg, curcumin 35 mg, d-α-tocopherol 10 mg for a total of 830 mg | (122) |
| ArtemiC oral spray (1 mL) | 6 mg artemisinin, 20 mg curcumin, 15 mg frankincense, 60 mg vitamin C | (127) |
| BCM-95 | Curcuma longa extract with essential oils from turmeric rhizome, rice flour, vegetable cellulose, vegetable stearate, silica | (116) |
| bioactive capsules | rutin (500 mg), 1.5 g fish oil (18% EPA and 7% DHA), 500 mg curcumin (95% curcuminoids) | (128) |
| C3 complex bioperine | curcuminoid extract containing curcumin, desmethoxycurcumin, bisdesmethoxycurcumin and piperine formulation | (51,61) |
| CartiJoint Forte | curcumin (BCM-95), chondroitin sulfate and glucosamine hydrochloride | (123) |
| Coltect tablet | curcumin 500 mg, green tea 250 mg, and selenium 100 μg | (130) |
| CUC-1 | 300 mg solution of curcumin | (129) |
| CuraMed | 552–578 mg of BCM-95 extracted in ethanol 99% (v/v) and 100% ethyl acetate +49–52 mg volatile oil from C. longa containing 22–23.4 mg aromatic turmerone + inactive excipients (120–140 mg) including phosphatidyl choline, medium chain TGs, glycerol, gelatin, yellow beeswax | (124) |
| Curamin | 350 mg BCM-95 + 150 mg of Boswellia serrata Roxb. ex Colebrgum resin extract corresponding to 75% boswellic acids and 10% 3-O-acetyl-11-keto-boswellic acid | (124) |
| Curcugreen | Dry rhizomes of turmeric extracted with ethyl acetate to form turmeric oleoresin, precipitated and combined with turmeric essential oil | (126) |
| Curcumall | A tincture of curcumin C3 95%, turmeric and ginger dissolved in glycerin and 0.4% alcohol | (131) |
| curcumin chitosan mouthwash | Purified curcuminoid powder 0.1 g (79:19:1 of curcumin/dimethoxycurcumin/bisdemethoxycurcumin) dissolved in 40 mL PEG, 25 mL of 2% low molecular weight chitosan | (87) |
| curcumin capsules from Theravalues Corporation, Tokyo, Japan | 10% curcumin, 2% other curcuminoids, 3.2% gum ghatti, 0.27% citric acid, 54.53% dextrin, and 30% maltose | (133) |
| curcumin forte | 95% curcumin plus 5% piperine | (86) |
| curcuminoid turmeric matrix formulation | 50% Total curcuminoids (41.2% curcumin, 7.3% desmethoxycurcumin, 1.5% bisdemethoxycurcumin), 3% essential oil, 2% protein, 40% total carbohydrate | (138) |
| curcuminoid turmeric oil formulation | 440 mg curcuminoid (347 mg curcumin, 84 mg desmethoxycurcumin, 9 mg bisdemethoxycurcumin), 38 mg of turmeric oil | (139,140) |
| Cureit/Acumin | 46.5% Total curcuminoids (36% curcumin, 9.0% desmethoxycurcumin, 1.5% bisdemethoxycurcumin), 43% total carbohydrates, 5% fiber, 2.4% proteins, 3.2% volatile oil containing aromatic turmerone, dihydroturmerone, turmeronol, curdione, bisacurone | (135) |
| Infla-Kine | Proprietary blend of Lactobacillus fermentum extract, burdock seed, zinc, lipoic acid, papaya enzyme, BCM-95 | (144) |
| Killox | 190 mg curcuminoids, 20 mg resveratrol, 100 mg NAC, 6 mg zinc with the formulation of enterosoma technology to obtain increased bioavailability | (146) |
| LCD capsule | Soft gel capsules containing lutein (20 mg), curcumin (200 mg total curcuminoids), zeaxanthin (4 mg) from marigold flower extract, algal source vitamin D3 (600 IU), medium chain triglyceride oil, linseed oil, olive oil, sunflower lecithin, tocopherol and thyme oil | (147) |
| natural product capsule by Vitacost | Each 500 mg capsule contain 150 mg curcumin, 75 mg resveratrol, 150 mg epigalloatechin-3-gallate, 125 mg soy isoflavone | (148) |
| Nutrafol women’s capsules | A proprietary blend of clinically tested and bio-optimized phytoactive extracts, vitamins, minerals and botanicals; major ingredients include standardized extracts of Ashwagandha, curcumin, piperine, capsiacin, hydrolyzed marine collagen, hyaluronic acid, organic kelp, saw palmetto, tocotrienol rich tocotrienol/tocopherol complex | (153) |
| PureVida | 460 mg of fish oil (DHA and EPA), 125 mg of Hytolive powder (12.5 mg of hydroxytyrosol), 50 mg of curcumin extract (47.5 mg of curcuminoids) | (150) |
| Reglicem | Chromium picolinate 100 μcg Cr, 200 mg curcumin dry extract, 200 mg berberine dry extract, 300 mg inositol, 40 mg banaba dry extract with 1% corosolic acid, silicon dioxide, magnesium stearate, dicalcium phosphate, microcrystalline cellulose | (151) |
| Turmix tablet | 300 mg curcumin plus 5 mg piperine | (113) |
| Turmix mouthwash | C. longa dry extract 0.1% w/v standardized to 95% curcumin (tetrahydrocurcumin) along with thymol, eucalyptol, clove oil, mentha oil, tea tree oil | (113) |
| Volatile oil formulation of curcumin | 85.9% curcuminoids (70.2% curcumin, 14.3% demethoxycurcumin, 1.4% bisdemethoxycurcumin), 7–9% essential oil naturally present in turmeric | (135) |
| WEC (hot water extract of curcumin) | C. longa rhizomes were crushed and incubated with hot water. The supernatant was concentrated, mixed with dextrin and spray-dried to obtain powder. The powder was later dissolved in dimethyl sulfoxide | (152) |
| Second-Generation Formulation | ||
| Actbiome | curcumin and asafetida complex was incorporated on to turmeric dietary fiber by spray drying process with complete natural matrix via polar–nonpolar sandwich technology | (154) |
| Algocur (Meriva formulation) | each tablet contains 1 g of Meriva | (199) |
| BioCurc/CLDM | 85% curcumin, 13% demethoxycurcumin, 2% bisdemethoxycurcumin, lauryl macrogol-32 glycerides, polysorbate-20, dl-α-tocopherol, hydroxyprolyl cellulose | (155) |
| CartiJoint Forte | Chondroitin sulfate, glucosamine hydrochloride, BCM-95 | |
| CHC (curcumin formulation with hydrophilic carrier) | Novel water-soluble formulation containing turmeric extract 20–28%, a hydrophilic carrier 63–75%, cellulose derivatives 10–40%, natural antioxidants 1–3% | (157) |
| CSL | curcumin/soy lecithin/microcrystalline cellulose in the ratio of 1:2:2 | (137) |
| curcumin nanomicelle gel from Sina Pharmaceuticals | 1% curcumin nanomicelle gel | (264) |
| curcuminoid cream from GPO Thailand | Tetrahydrocurcuminoid in phosphatidyl choline liposomes | (202) |
| curcuminoid micelles | 7% native curcumin powder containing 82% curcumin, 16% demethoxycurcumin and 2% bisdemethoxycurcumin and 93% Tween-80 filled in Licaps; finally, each capsule contained 20.1 mg curcumin, 3.9 mg demethoxycurcumin, and 0.5 mg bisdemethoxycurcumin | (160,161,163) |
| Curserin | 200 mg curcumin, 120 mg phosphatidylserine, 480 mg phosphatidylcholine and 8 mg piperine from Piper nigrum L. dry extract | (159) |
| CW8 | curcumin in complex with γ-cyclodextrin | (137) |
| FLAVOMEGA | fructose, phospholipidic curcumin, acetyl carnitine-HCL, ascorbic acid, flavoring, coenzyme Q10, Skullcap, Baicalin, green tea catechins, antiagglomerant, acesulfame potassium, sucralose | (164) |
| Flexofytol | bio-optimized curcumin 42 mg mixed with polysorbate Tween-80 | (165,166) |
| HydroCurc | 80% curcumin, 17% demethoxycurcumin, 3% bisdemethoxycurcumin, entrapped in LipiSperse delivery system | (167) |
| Ialuril soft gel tablets | Oral food integrator containing curcumin, quercetin, hyaluronic acid and chondroitin sulfate | (145) |
| Meriva | curcumin complexed with phosphatidyl choline | (179) |
| NE65 | Lipoid S LPC65 (5% w/w), olive oil (20% w/w), potassium sorbate (0.1% w/w) and distilled water | (200) |
| NLC65 | Lipoid S LPC65 (5% w/w), olive oil (2.22% w/w), precirol ATO5 (7.77% w/w) and distilled water | (200) |
| NLC80 | Lipoid S LPC80 (5% w/w), olive oil (2.22% w/w), precirol ATO5 (7.77% w/w) and distilled water | (200) |
| phospholipid curcumin formulation | 19.8% curcuminoids (16.1% curcumin, 3.2% demethoxycurcumin, 0.5% bisdemethoxycurcumin), 40% phospholipids, 40% microcrystalline cellulose | (135) |
| phospholipidated curcumin | ∼20% curcumin and soy phosphatidyl choline in 1:2 weight ratio, 2 parts of microcrystalline cellulose | (204) |
| theracurmin | curcumin dispersed in colloidal nanoparticles- Gum ghatti obtained from exudation of ghatti trees was dissolved in water and mixed with curcumin powder and glycerin, wet grinded and dispersed as colloidal nanoparticle by a high-pressure homogenizer | (282,283) |
| theracurmin beverage | Water, sugar syrup (high-fructose corn syrup, sugar), cinnamon extract, ginger, alanine, acidulant, Theracurmin, vitamin C, flavor, sweetner (licorice, sucralose), niacinamide, calcium pantothenate, vitamin B6, vitamin B2, vitamin B1, vitamin B12 | (286) |
| Third-Generation Formulation | ||
| curcumagalactomannosides | Novel oral delivery for of curcumin prepared using noncovalent complex formation between curcumin and fenugreek galactomannans | (301) |
| curcuRouge | Amorphous formulation of curcumin, modified starch, corn-starch containing 37 w/w% of curcumin | (297) |
| Curcuwin Ultra+ | 63–75% polyvinyl pyrrolidine, 10–40% cellulosic derivatives, 1–3% natural antioxidants, 20–28% turmeric extract | (47,304) |
| Longvida | curcumin in solid lipid formulation containing proprietary blend of vegetable derived stearic acid dextrin, hydroxypropyl methylcellulose, soy lecithin, ascorbyl palmitate, silicon dioxide | (306,308) |
a
Abbreviation: CLDM, Curcumin liquid droplet micromicellar formulation; DHA, Docosahexaenoic acid; EPA, icosapentaenoic acid; HCl, Hydrogen chloride.