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. 2023 Mar 30;2023(3):CD001233. doi: 10.1002/14651858.CD001233.pub4

Comparison 32. Any mechanical method and prostaglandin E2 versus low dose misoprostol alone: all women.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
32.1 Vaginal delivery not achieved in 24 hours 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 0.32 [0.12, 0.82]
32.2 Caesarean section 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 1.09 [0.58, 2.04]
32.3 Serious neonatal morbidity/perinatal death 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 0.19 [0.01, 3.90]
32.4 Cervix unfavourable/unchanged after 12‐24 hours 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 0.41 [0.25, 0.67]
32.5 Oxytocin augmentation 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 1.21 [1.01, 1.46]
32.6 Uterine hyperstimulation without FHR changes 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 4.05 [1.44, 11.38]
32.7 Instrumental vaginal delivery 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 1.26 [0.77, 2.04]
32.8 Meconium‐stained liquor 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 0.56 [0.23, 1.32]
32.9 Apgar score < 7 at 5 minutes 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 1.91 [0.18, 20.51]
32.10 Neonatal intensive care unit admission 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 0.64 [0.31, 1.31]
32.11 Perinatal death 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 0.19 [0.01, 3.90]
32.12 Chorioamnionitis 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 1.91 [0.18, 20.51]
32.13 Endometritis 1 127 Risk Ratio (M‐H, Fixed, 95% CI) 1.91 [0.36, 10.05]