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. 2023 Mar 30;2023(3):CD001233. doi: 10.1002/14651858.CD001233.pub4

Lyndrup 1989.

Study characteristics
Methods RCT.
Participants Woman with unfavourable cervix.
Interventions 4 groups:
  1. oxytocin without Lamicel (according to a fixed schedule, with a max of 32 mU per minute) (24 women);

  2. oxytocin with Lamicel (1 unit) (22 women);

  3. PGs without Lamicel (2.5 mg PGE2) (19 women);

  4. PGs with Lamicel (1 unit) (20 women).

Outcomes CS, forceps or vacuum extraction, endometritis.
Notes Setting: Denmark
Study period: not reported
Funding: not reported
Declarations of interest: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Only reported women were randomised by sealed envelope method
Allocation concealment (selection bias) Low risk Sealed envelopes
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Not feasible due to nature of intervention
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Not reported
Incomplete outcome data (attrition bias)
All outcomes High risk 6 women excluded for protocol violation.
Selective reporting (reporting bias) Unclear risk No outcomes were pre specified in method section.
Other bias Low risk No other bias detected