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. 2023 Mar 30;25:34. doi: 10.1186/s13058-023-01639-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Distinct patterns of immune cell characteristics between HER2_low TNBC and HER2_neg TNBC. (A) scTCR-seq analysis shows TCR diversity in HER2_neg TNBC and HER2_low TNBC. The horizontal axis lists T cell types, and the vertical axis shows individual samples and TNBC groupings. Different colors represent different frequencies of TCR clonotypes. Single, unique TCR clonotypes; medium, TCR clonotypes with a frequency between 1 and 10; large, TCR clonotypes with a frequency > 10.The size of the circle represents the number of T cells. (B) Bar plot shows infiltration levels of different macrophages in HER2_neg and HER2_low TNBC groups. M, all macrophages; M1, M1 macrophages; M2, M2 macrophages. (C) Correlations between ERBB2 mRNA expression level and various immune cell functions in TNBC (GSE76124, GSE95700, GSE103091, GSE135565, GSE157284 and GSE167213). P, Spearman correlation analysis; the numbers on the right are p values; p values in red indicate a significant positive correlation, while those in blue indicate a significant negative correlation. (D) Correlations between the expressions of characteristic immunoglobulin genes (IGHG1, IGKC) and the signature molecules in macrophage recruitment (CCR2, CCR5, CSF1R, ITGA4), using Spearman correlation analysis; P < 0.05 indicates statistical significance. (E) Comparison of immune scores in TNBC samples with different ERBB2 expression levels. The median expression level of ERBB2 was used as the cut-off value