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. 2023 Mar 30;25:34. doi: 10.1186/s13058-023-01639-y

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Characteristic changes of immune microenvironment in HER2_neg TNBC patients before and after neoadjuvant immunotherapy. (A) Comparison of the abundance of the subclusters of T cells before and after treatment of HER2_neg TNBC. CD8Teff, CD8⁺ effector T cells; HelperT, CD4⁺ helper T cells. (B) Pathway enrichment analysis of up-regulated genes in T cells after neoadjuvant immunotherapy in HER2_neg TNBC compared with treatment-naïve T cells. (C) ScTCR-seq analysis in HER2_neg TNBC before and after treatment by four different scoring methods. (D) Comparison of the abundance of the subclusters of microphages before and after treatment in HER2_neg TNBC patients. M1, M1 microphages; M2, M2 microphages; TAMs, tumor-associated microphages; MatureDCs, Mature dendritic cells; cDC, classical dendritic cells